Sparseness Constrains the Prolongation of Memory Lifetime via Synaptic Metaplasticity
نویسندگان
چکیده
منابع مشابه
Metaplasticity: the plasticity of synaptic plasticity.
In this paper, we review experimental evidence for a novel form of persistent synaptic plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it is not necessarily expressed as a change in the efficacy of normal synaptic transmission. Instead, it is manifest as a change in the ability to induce subsequent synaptic plasticity, such as long-term potenti...
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In many regions of the brain, the activity-dependent changes in synaptic strength depend on the frequency and timing of presynaptic stimulation and postsynaptic activity (synaptic plasticity), as well as the history of activity at those synapses (metaplasticity). The Bienenstock, Cooper and Munro (BCM) theory made several assumptions about how synapses modify and these have helped to guide vari...
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Lateral diffusion of glutamate receptors was proposed as a mechanism for regulating receptor numbers at synapses and affecting synaptic functions, especially the efficiency of synaptic transmission. However, a direct link between receptor lateral diffusion and change in synaptic function has not yet been established. In the present study, we demonstrated NMDA receptor (NMDAR) lateral diffusion ...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2007
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhm037